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Groeger M, Matsuo K, Heidary Arash E, Pereira A, Le Guillou D, Pino C, Telles-Silva KA, Maher JJ, Hsiao EC, Willenbring H
Modeling and therapeutic targeting of inflammation-induced hepatic insulin resistance using human iPSC-derived hepatocytes and macrophages.
Nature communications, 2023-07-03.
Qi L, Matsuo K, Pereira A, Lee YT, Zhong F, He Y, Zushin PH, Gr?ger M, Sharma A, Willenbring H, Hsiao EC, Stahl A
Human iPSC-Derived Proinflammatory Macrophages cause Insulin Resistance in an Isogenic White Adipose Tissue Microphysiological System.
Small (Weinheim an der Bergstrasse, Germany), 2023-04-27.
Laemmle A, Häberle J, Willenbring H
Reply to "The Role of Aquaporin 9 in Modeling of Ornithine Transcarbamylase Deficiency".
Hepatology (Baltimore, Md.), 2021-12-21.
Laemmle A, Poms M, Hsu B, Borsuk M, Rüfenacht V, Robinson J, Sadowski MC, Nuoffer JM, Häberle J, Willenbring H
Aquaporin 9 Induction in Human iPSC-derived Hepatocytes Facilitates Modeling of Ornithine Transcarbamylase Deficiency.
Hepatology (Baltimore, Md.), 2021-11-16.
Lee-Montiel FT, Laemmle A, Charwat V, Dumont L, Lee CS, Huebsch N, Okochi H, Hancock MJ, Siemons B, Boggess SC, Goswami I, Miller EW, Willenbring H, Healy KE
Integrated Isogenic Human Induced Pluripotent Stem Cell-Based Liver and Heart Microphysiological Systems Predict Unsafe Drug-Drug Interaction.
Frontiers in pharmacology, 2021-05-07.
Duwaerts CC, Le Guillou D, Her CL, Phillips NJ, Willenbring H, Mattis AN, Maher JJ
iPSC-derived hepatocytes from patients with nonalcoholic fatty liver disease display a disease-specific gene expression profile.
Gastroenterology, 2021-02-25.
Emerging cell therapy for biliary diseases.
Science (New York, N.Y.), 2021-02-19.
Kurial SNT, Willenbring H
Transcriptomic traces of adult human liver progenitor cells.
Hepatology (Baltimore, Md.), 2020-01-28.
Chen F, Jimenez RJ, Sharma K, Luu HY, Hsu BY, Ravindranathan A, Stohr BA, Willenbring H
Broad Distribution of Hepatocyte Proliferation in Liver Homeostasis and Regeneration.
Cell stem cell, 2019-12-19.
Huck I, Gunewardena S, Espanol-Suner R, Willenbring H, Apte U
Hepatocyte Nuclear Factor 4 alpha (HNF4a) Activation is Essential for Termination of Liver Regeneration.
Hepatology (Baltimore, Md.), 2018-12-05.
Schaub JR, Huppert KA, Kurial SNT, Hsu BY, Cast AE, Donnelly B, Karns RA, Chen F, Rezvani M, Luu HY, Mattis AN, Rougemont AL, Rosenthal P, Huppert SS, Willenbring H
De novo formation of the biliary system by TGFß-mediated hepatocyte transdifferentiation.
Nature, 2018-05-02.
Ian Huck,Sumedha Gunewardena,Regina Espanol-Suner,Holger Willenbring,Udayan Apte
Hepatocyte Nuclear Factor 4 alpha (HNF4a) Activation is Essential for Termination of Liver Regeneration.
bioRxiv, 2018-04-20.
Abou-Alfa GK, Andersen JB, Chapman W, Choti M, Forbes SJ, Gores GJ, Hong TS, Harding JJ, Vander Heiden MG, Javle M, Kelley RK, Kwong LN, Lowery M, Merrell A, Miyabe K, Rhim A, Saha S, Sia D, Tanasanvimon S, Venook A, Valle JW, Walesky C, Whetstine J, Willenbring H, Zhu AX, Mayer D, Stanger BZ
Advances in cholangiocarcinoma research: report from the third Cholangiocarcinoma Foundation Annual Conference.
Journal of gastrointestinal oncology, 2016-12-01.
Rezvani M, Español-Suñer R, Malato Y, Dumont L, Grimm AA, Kienle E, Bindman JG, Wiedtke E, Hsu BY, Naqvi SJ, Schwabe RF, Corvera CU, Grimm D, Willenbring H
In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis.
Cell stem cell, 2016-06-02.
Rezvani M, Grimm AA, Willenbring H
Assessing the therapeutic potential of lab-made hepatocytes.
Hepatology (Baltimore, Md.), 2016-05-26.
Desai SS, Tung JC, Zhou VX, Grenert JP, Malato Y, Rezvani M, Español-Suñer R, Willenbring H, Weaver VM, Chang TT
Physiological ranges of matrix rigidity modulate primary mouse hepatocyte function in part through hepatocyte nuclear factor 4 alpha.
Hepatology (Baltimore, Md.), 2016-03-09.
Mattis AN, Song G, Hitchner K, Kim RY, Lee AY, Sharma AD, Malato Y, McManus MT, Esau CC, Koller E, Koliwad S, Lim LP, Maher JJ, Raffai RL, Willenbring H
A screen in mice uncovers repression of lipoprotein lipase by microRNA-29a as a mechanism for lipid distribution away from the liver.
Hepatology (Baltimore, Md.), 2014-11-24.
Hentzschel F, Hammerschmidt-Kamper C, Börner K, Heiss K, Knapp B, Sattler JM, Kaderali L, Castoldi M, Bindman JG, Malato Y, Willenbring H, Mueller AK, Grimm D
AAV8-mediated in vivo overexpression of miR-155 enhances the protective capacity of genetically attenuated malarial parasites.
Molecular therapy : the journal of the American Society of Gene Therapy, 2014-09-05.
Johanna R. Schaub,Yann Malato,Coralie Gormond,Holger Willenbring
Evidence against a Stem Cell Origin of New Hepatocytes in a Common Mouse Model of Chronic Liver Injury.
Cell Reports, 2014-09-01.
Schaub JR, Malato Y, Gormond C, Willenbring H
Evidence against a stem cell origin of new hepatocytes in a common mouse model of chronic liver injury.
Cell reports, 2014-08-14.
Espejel S, Eckardt S, Harbell J, Roll GR, McLaughlin KJ, Willenbring H
Brief report: Parthenogenetic embryonic stem cells are an effective cell source for therapeutic liver repopulation.
Stem cells (Dayton, Ohio), 2014-07-01.
Lee RH, Roll G, Nguyen V, Willenbring H, Tang Q, Kang SM, Stock PG
Failure to achieve normal metabolic response in non-obese diabetic mice and streptozotocin-induced diabetic mice after transplantation of primary murine hepatocytes electroporated with the human proinsulin gene (p3MTChins).
Transplantation proceedings, 2014-07-01.
Ng R, Wu H, Xiao H, Chen X, Willenbring H, Steer CJ, Song G
Inhibition of microRNA-24 expression in liver prevents hepatic lipid accumulation and hyperlipidemia.
Hepatology (Baltimore, Md.), 2014-05-19.
Zhu S, Rezvani M, Harbell J, Mattis AN, Wolfe AR, Benet LZ, Willenbring H, Ding S
Mouse liver repopulation with hepatocytes generated from human fibroblasts.
Nature, 2014-02-23.
Mitchell C, Willenbring H
Addendum: A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice.
Nature protocols, 2014-01-01.
Mathur A, Loskill P, Hong S, Lee J, Marcus SG, Dumont L, Conklin BR, Willenbring H, Lee LP, Healy KE
Human induced pluripotent stem cell-based microphysiological tissue models of myocardium and liver for drug development.
Stem cell research & therapy, 2013-12-20.
Lim L, Balakrishnan A, Huskey N, Jones KD, Jodari M, Ng R, Song G, Riordan J, Anderton B, Cheung ST, Willenbring H, Dupuy A, Chen X, Brown D, Chang AN, Goga A
MicroRNA-494 within an oncogenic microRNA megacluster regulates G1/S transition in liver tumorigenesis through suppression of mutated in colorectal cancer.
Hepatology (Baltimore, Md.), 2013-11-22.
Willenbring H, Soto-Gutierrez A
Transplantable liver organoids made from only three ingredients.
Cell stem cell, 2013-08-01.
Ma X, Duan Y, Tschudy-Seney B, Roll G, Behbahan IS, Ahuja TP, Tolstikov V, Wang C, McGee J, Khoobyari S, Nolta JA, Willenbring H, Zern MA
Highly efficient differentiation of functional hepatocytes from human induced pluripotent stem cells.
Stem cells translational medicine, 2013-05-16.
Willenbring H, Grompe M
A therapy for liver failure found in the JNK yard.
Cell, 2013-04-11.
M Evert,B Fan,Y Malato,S Ribback,F Dombrowski,H Willenbring,X Chen,DF Calvisi
Akt/Notch activation drives rapid cholangiocarcinoma development originating from mature hepatocytes in the mouse.
Zeitschrift für Gastroenterologie, 2013-01-11.
Fan B, Malato Y, Calvisi DF, Naqvi S, Razumilava N, Ribback S, Gores GJ, Dombrowski F, Evert M, Chen X, Willenbring H
Cholangiocarcinomas can originate from hepatocytes in mice.
The Journal of clinical investigation, 2012-07-17.
Mattis AN, Willenbring H
A ZFN/piggyBac step closer to autologous liver cell therapy.
Hepatology (Baltimore, Md.), 2012-06-01.
Ng R, Song G, Roll GR, Frandsen NM, Willenbring H
A microRNA-21 surge facilitates rapid cyclin D1 translation and cell cycle progression in mouse liver regeneration.
The Journal of clinical investigation, 2012-02-13.
Rountree CB, Mishra L, Willenbring H
Stem cells in liver diseases and cancer: recent advances on the path to new therapies.
Hepatology (Baltimore, Md.), 2012-01-01.
Malato Y, Naqvi S, Schürmann N, Ng R, Wang B, Zape J, Kay MA, Grimm D, Willenbring H
Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration.
The Journal of clinical investigation, 2011-11-21.
Willenbring H
A simple code for installing hepatocyte function.
Cell stem cell, 2011-08-05.
Eckardt S, McLaughlin KJ, Willenbring H
Mouse chimeras as a system to investigate development, cell and tissue function, disease mechanisms and organ regeneration.
Cell cycle (Georgetown, Tex.), 2011-07-01.
D'Alessio JA, Ng R, Willenbring H, Tjian R
Core promoter recognition complex changes accompany liver development.
Proceedings of the National Academy of Sciences of the United States of America, 2011-02-22.
Malato Y, Willenbring H
The MAP3K TAK1: a chock block to liver cancer formation.
Hepatology (Baltimore, Md.), 2010-10-01.
Roll GR, Willenbring H
Transplanted nonviable human hepatocytes produce appreciable serum albumin levels in mice.
Stem cell research, 2010-08-05.
Espejel S, Roll GR, McLaughlin KJ, Lee AY, Zhang JY, Laird DJ, Okita K, Yamanaka S, Willenbring H
Induced pluripotent stem cell-derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice.
The Journal of clinical investigation, 2010-08-25.
Saunders LR, Sharma AD, Tawney J, Nakagawa M, Okita K, Yamanaka S, Willenbring H, Verdin E
miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues.
Aging, 2010-07-01.
Erker L, Azuma H, Lee AY, Guo C, Orloff S, Eaton L, Benedetti E, Jensen B, Finegold M, Willenbring H, Grompe M
Therapeutic liver reconstitution with murine cells isolated long after death.
Gastroenterology, 2010-06-02.
Song G, Sharma AD, Roll GR, Ng R, Lee AY, Blelloch RH, Frandsen NM, Willenbring H
MicroRNAs control hepatocyte proliferation during liver regeneration.
Hepatology (Baltimore, Md.), 2010-05-01.
Willenbring H, Sharma AD, Vogel A, Lee AY, Rothfuss A, Wang Z, Finegold M, Grompe M
Loss of p21 permits carcinogenesis from chronically damaged liver and kidney epithelial cells despite unchecked apoptosis.
Cancer cell, 2008-07-08.
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, 2008-03-01.
Mitchell C, Willenbring H
A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice.
Nature protocols, 2008-01-01.
Ramalho-Santos M, Willenbring H
On the origin of the term "stem cell".
Cell stem cell, 2007-06-07.
Bailey AS, Willenbring H, Jiang S, Anderson DA, Schroeder DA, Wong MH, Grompe M, Fleming WH
Myeloid lineage progenitors give rise to vascular endothelium.
Proceedings of the National Academy of Sciences of the United States of America, 2006-08-18.
Rizvi AZ, Swain JR, Davies PS, Bailey AS, Decker AD, Willenbring H, Grompe M, Fleming WH, Wong MH
Bone marrow-derived cells fuse with normal and transformed intestinal stem cells.
Proceedings of the National Academy of Sciences of the United States of America, 2006-04-10.
Held PK, Al-Dhalimy M, Willenbring H, Akkari Y, Jiang S, Torimaru Y, Olson S, Fleming WH, Finegold M, Grompe M
In vivo genetic selection of renal proximal tubules.
Molecular therapy : the journal of the American Society of Gene Therapy, Jan-2006;13(1):49-58.  Epub 2005 Oct 10.
View Abstract | PubMed AbstractPlus 
Vogel A, Aslan JE, Willenbring H, Klein C, Finegold M, Mount H, Thomas G, Grompe M
Sustained phosphorylation of Bid is a marker for resistance to Fas-induced apoptosis during chronic liver diseases.
Gastroenterology, 2006-01-01.
Held PK, Al-Dhalimy M, Willenbring H, Akkari Y, Jiang S, Torimaru Y, Olson S, Fleming WH, Finegold M, Grompe M
In vivo genetic selection of renal proximal tubules.
Molecular therapy : the journal of the American Society of Gene Therapy, 2005-10-10.
Willenbring H
Therapeutic cell fusion.
The British journal of surgery, 2005-08-01.
Willenbring H, Grompe M
Delineating the hepatocyte's hematopoietic fusion partner.
Cell cycle (Georgetown, Tex.), 2004-12-15.
Willenbring H, Bailey AS, Foster M, Akkari Y, Dorrell C, Olson S, Finegold M, Fleming WH, Grompe M
Myelomonocytic cells are sufficient for therapeutic cell fusion in liver.
Nature medicine, 2004-06-13.
Willenbring H, Grompe M
Embryonic versus adult stem cell pluripotency: in liver only fusion matters.
Journal of assisted reproduction and genetics, 2003-10-01.
Wang X, Willenbring H, Akkari Y, Torimaru Y, Foster M, Al-Dhalimy M, Lagasse E, Finegold M, Olson S, Grompe M
Cell fusion is the principal source of bone-marrow-derived hepatocytes.
Nature, 2003-03-30.
Linnebank M, Tschiedel E, Häberle J, Linnebank A, Willenbring H, Kleijer WJ, Koch HG
Argininosuccinate lyase (ASL) deficiency: mutation analysis in 27 patients and a completed structure of the human ASL gene.
Human genetics, Oct-2002;111(4-5):350-9.
View Abstract | PubMed AbstractPlus 
Linnebank M, Tschiedel E, Häberle J, Linnebank A, Willenbring H, Kleijer WJ, Koch HG
Argininosuccinate lyase (ASL) deficiency: mutation analysis in 27 patients and a completed structure of the human ASL gene.
Human genetics, 2002-08-14.
Homberger A, Linnebank M, Winter C, Willenbring H, Marquardt T, Harms E, Koch HG
Genomic structure and transcript variants of the human methylenetetrahydrofolate reductase gene.
European journal of human genetics : EJHG, 2000-09-01.
Poremba C, Willenbring H, Hero B, Christiansen H, Schäfer KL, Brinkschmidt C, Jürgens H, Böcker W, Dockhorn-Dworniczak B
Telomerase activity distinguishes between neuroblastomas with good and poor prognosis.
Annals of oncology : official journal of the European Society for Medical Oncology, 1999-06-01.
Poremba C, Böcker W, Willenbring H, Schäfer KL, Otterbach F, Bürger H, Diallo R, Dockhorn-Dworniczak B
Telomerase activity in human proliferative breast lesions.
International journal of oncology, 1998-03-01.
Hiort O, Sinnecker GH, Willenbring H, Lehners A, Zöllner A, Struve D
Nonisotopic single strand conformation analysis of the 5 alpha-reductase type 2 gene for the diagnosis of 5 alpha-reductase deficiency.
The Journal of clinical endocrinology and metabolism, 1996-09-01.
Hiort O, Willenbring H, Albers N, Hecker W, Engert J, Dibbelt L, Sinnecker GH
Molecular genetic analysis and human chorionic gonadotropin stimulation tests in the diagnosis of prepubertal patients with partial 5 alpha-reductase deficiency.
European journal of pediatrics, 1996-06-01.
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