Willenbring Lab »  Publications
Willenbring Lab »  Publications


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Desai SS, Tung JC, Zhou VX, Grenert JP, Malato Y, Rezvani M, Español-Suñer R, Willenbring H, Weaver VM, Chang TT
Physiological ranges of matrix rigidity modulate primary mouse hepatocyte function in part through hepatocyte nuclear factor 4 alpha.
Hepatology (Baltimore, Md.), Jul-2016;64(1):261-75.  Epub 2016 Mar 9.
Rezvani M, Grimm AA, Willenbring H
Assessing the therapeutic potential of lab-made hepatocytes.
Hepatology (Baltimore, Md.), Jul-2016;64(1):287-94.  Epub 2016 May 26.
Rezvani M, Español-Suñer R, Malato Y, Dumont L, Grimm AA, Kienle E, Bindman JG, Wiedtke E, Hsu BY, Naqvi SJ, Schwabe RF, Corvera CU, Grimm D, Willenbring H
In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis.
Cell stem cell, Jun-2-2016;18(6):809-16.
Hentzschel F, Hammerschmidt-Kamper C, Börner K, Heiss K, Knapp B, Sattler JM, Kaderali L, Castoldi M, Bindman JG, Malato Y, Willenbring H, Mueller AK, Grimm D
AAV8-mediated in vivo overexpression of miR-155 enhances the protective capacity of genetically attenuated malarial parasites.
Molecular therapy : the journal of the American Society of Gene Therapy, Dec-2014;22(12):2130-41.  Epub 2014 Sep 05.
Mattis AN, Song G, Hitchner K, Kim RY, Lee AY, Sharma AD, Malato Y, McManus MT, Esau CC, Koller E, Koliwad S, Lim LP, Maher JJ, Raffai RL, Willenbring H
A screen in mice uncovers repression of lipoprotein lipase by microRNA-29a as a mechanism for lipid distribution away from the liver.
Hepatology (Baltimore, Md.), Aug-18-2014;[Epub ahead of print].
Schaub JR, Malato Y, Gormond C, Willenbring H
Evidence against a Stem Cell Origin of New Hepatocytes in a Common Mouse Model of Chronic Liver Injury.
Cell reports, Aug-13-2014;[Epub ahead of print].
Ng R, Wu H, Xiao H, Chen X, Willenbring H, Steer CJ, Song G
Inhibition of microRNA-24 expression in liver prevents hepatic lipid accumulation and hyperlipidemia.
Hepatology (Baltimore, Md.), Aug-2014;60(2):554-64.  Epub 2014 May 19.
Espejel S, Eckardt S, Harbell J, Roll GR, McLaughlin KJ, Willenbring H
Brief report: Parthenogenetic embryonic stem cells are an effective cell source for therapeutic liver repopulation.
Stem cells (Dayton, Ohio), Jul-2014;32(7):1983-8.
Lee RH, Roll G, Nguyen V, Willenbring H, Tang Q, Kang SM, Stock PG
Failure to Achieve Normal Metabolic Response in Non-Obese Diabetic Mice and Streptozotocin-Induced Diabetic Mice After Transplantation of Primary Murine Hepatocytes Electroporated With the Human Proinsulin Gene (p3MTChins).
Transplantation proceedings, 2014 Jul-Aug;46(6):2002-6.
Mitchell C, Willenbring H
Addendum: A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice.
Nature protocols, Jun-2014;9(6):.
Zhu S, Rezvani M, Harbell J, Mattis AN, Wolfe AR, Benet LZ, Willenbring H, Ding S
Mouse liver repopulation with hepatocytes generated from human fibroblasts.
Nature, Apr-3-2014;508(7494):93-7.  Epub 2014 Feb 23.
Lim L, Balakrishnan A, Huskey N, Jones KD, Jodari M, Ng R, Song G, Riordan J, Anderton B, Cheung ST, Willenbring H, Dupuy A, Chen X, Brown D, Chang AN, Goga A
MicroRNA-494 within an oncogenic microRNA megacluster regulates G1/S transition in liver tumorigenesis through suppression of mutated in colorectal cancer.
Hepatology (Baltimore, Md.), Jan-2014;59(1):202-15.  Epub 2013 Nov 22.
Ma X, Duan Y, Tschudy-Seney B, Roll G, Behbahan IS, Ahuja TP, Tolstikov V, Wang C, McGee J, Khoobyari S, Nolta JA, Willenbring H, Zern MA
Highly efficient differentiation of functional hepatocytes from human induced pluripotent stem cells.
Stem cells translational medicine, Jun-2013;2(6):409-19.  Epub 2013 May 16.
Mathur A, Loskill P, Hong S, Lee J, Marcus SG, Dumont L, Conklin BR, Willenbring H, Lee LP, Healy KE
Human induced pluripotent stem cell-based microphysiological tissue models of myocardium and liver for drug development.
Stem cell research & therapy, 2013;4 Suppl 1:S14.  Epub 2013 Dec 20.
Fan B, Malato Y, Calvisi DF, Naqvi S, Razumilava N, Ribback S, Gores GJ, Dombrowski F, Evert M, Chen X, Willenbring H
Cholangiocarcinomas can originate from hepatocytes in mice.
The Journal of clinical investigation, Aug-1-2012;122(8):2911-5.  Epub 2012 Jul 17.
Mattis AN, Willenbring H
A ZFN/piggyBac step closer to autologous liver cell therapy.
Hepatology (Baltimore, Md.), Jun-2012;55(6):2033-5.
Ng R, Song G, Roll GR, Frandsen NM, Willenbring H
A microRNA-21 surge facilitates rapid cyclin D1 translation and cell cycle progression in mouse liver regeneration.
The Journal of clinical investigation, Mar-1-2012;122(3):1097-108.  Epub 2012 Feb 13.
Rountree CB, Mishra L, Willenbring H
Stem cells in liver diseases and cancer: recent advances on the path to new therapies.
Hepatology (Baltimore, Md.), Jan-2012;55(1):298-306.
Malato Y, Naqvi S, Schürmann N, Ng R, Wang B, Zape J, Kay MA, Grimm D, Willenbring H
Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration.
The Journal of clinical investigation, Dec-2011;121(12):4850-60.  Epub 2011 Nov 21.
Willenbring H
A simple code for installing hepatocyte function.
Cell stem cell, Aug-5-2011;9(2):89-91.
Eckardt S, McLaughlin KJ, Willenbring H
Mouse chimeras as a system to investigate development, cell and tissue function, disease mechanisms and organ regeneration.
Cell cycle (Georgetown, Tex.), Jul-1-2011;10(13):2091-9.  Epub 2011 Jul 01.
D'Alessio JA, Ng R, Willenbring H, Tjian R
Core promoter recognition complex changes accompany liver development.
Proceedings of the National Academy of Sciences of the United States of America, Mar-8-2011;108(10):3906-11.  Epub 2011 Feb 22.
Roll GR, Willenbring H
Transplanted nonviable human hepatocytes produce appreciable serum albumin levels in mice.
Stem cell research, Nov-2010;5(3):267-70.  Epub 2010 Aug 5.
Malato Y, Willenbring H
The MAP3K TAK1: a chock block to liver cancer formation.
Hepatology (Baltimore, Md.), Oct-2010;52(4):1506-9.
Espejel S, Roll GR, McLaughlin KJ, Lee AY, Zhang JY, Laird DJ, Okita K, Yamanaka S, Willenbring H
Induced pluripotent stem cell-derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice.
The Journal of clinical investigation, Sep-2010;120(9):3120-6.  Epub 2010 Aug 25.
Erker L, Azuma H, Lee AY, Guo C, Orloff S, Eaton L, Benedetti E, Jensen B, Finegold M, Willenbring H, Grompe M
Therapeutic liver reconstitution with murine cells isolated long after death.
Gastroenterology, Sep-2010;139(3):1019-29.  Epub 2010 Jun 2.
Saunders LR, Sharma AD, Tawney J, Nakagawa M, Okita K, Yamanaka S, Willenbring H, Verdin E
miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues.
Aging, Jul-2010;2(7):415-31.
Song G, Sharma AD, Roll GR, Ng R, Lee AY, Blelloch RH, Frandsen NM, Willenbring H
MicroRNAs control hepatocyte proliferation during liver regeneration.
Hepatology (Baltimore, Md.), May-2010;51(5):1735-43.
Willenbring H, Sharma AD, Vogel A, Lee AY, Rothfuss A, Wang Z, Finegold M, Grompe M
Loss of p21 permits carcinogenesis from chronically damaged liver and kidney epithelial cells despite unchecked apoptosis.
Cancer cell, Jul-8-2008;14(1):59-67.
Mitchell C, Willenbring H
A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice.
Nature protocols, 2008;3(7):1167-70.
Ramalho-Santos M, Willenbring H
On the origin of the term "stem cell".
Cell stem cell, Jun-7-2007;1(1):35-8.
Bailey AS, Willenbring H, Jiang S, Anderson DA, Schroeder DA, Wong MH, Grompe M, Fleming WH
Myeloid lineage progenitors give rise to vascular endothelium.
Proceedings of the National Academy of Sciences of the United States of America, Aug-29-2006;103(35):13156-61.  Epub 2006 Aug 18.
Rizvi AZ, Swain JR, Davies PS, Bailey AS, Decker AD, Willenbring H, Grompe M, Fleming WH, Wong MH
Bone marrow-derived cells fuse with normal and transformed intestinal stem cells.
Proceedings of the National Academy of Sciences of the United States of America, Apr-18-2006;103(16):6321-5.  Epub 2006 Apr 10.
Vogel A, Aslan JE, Willenbring H, Klein C, Finegold M, Mount H, Thomas G, Grompe M
Sustained phosphorylation of Bid is a marker for resistance to Fas-induced apoptosis during chronic liver diseases.
Gastroenterology, Jan-2006;130(1):104-19.
Held PK, Al-Dhalimy M, Willenbring H, Akkari Y, Jiang S, Torimaru Y, Olson S, Fleming WH, Finegold M, Grompe M
In vivo genetic selection of renal proximal tubules.
Molecular therapy : the journal of the American Society of Gene Therapy, Jan-2006;13(1):49-58.  Epub 2005 Oct 10.
Willenbring H, Grompe M
Delineating the hepatocyte's hematopoietic fusion partner.
Cell cycle (Georgetown, Tex.), Dec-2004;3(12):1489-91.
Willenbring H, Bailey AS, Foster M, Akkari Y, Dorrell C, Olson S, Finegold M, Fleming WH, Grompe M
Myelomonocytic cells are sufficient for therapeutic cell fusion in liver.
Nature medicine, Jul-2004;10(7):744-8.
Willenbring H, Grompe M
Embryonic versus adult stem cell pluripotency: in liver only fusion matters.
Journal of assisted reproduction and genetics, Oct-2003;20(10):393-4.
Wang X, Willenbring H, Akkari Y, Torimaru Y, Foster M, Al-Dhalimy M, Lagasse E, Finegold M, Olson S, Grompe M
Cell fusion is the principal source of bone-marrow-derived hepatocytes.
Nature, Apr-24-2003;422(6934):897-901.
Linnebank M, Tschiedel E, Häberle J, Linnebank A, Willenbring H, Kleijer WJ, Koch HG
Argininosuccinate lyase (ASL) deficiency: mutation analysis in 27 patients and a completed structure of the human ASL gene.
Human genetics, Oct-2002;111(4-5):350-9.
Homberger A, Linnebank M, Winter C, Willenbring H, Marquardt T, Harms E, Koch HG
Genomic structure and transcript variants of the human methylenetetrahydrofolate reductase gene.
European journal of human genetics : EJHG, Sep-2000;8(9):725-9.